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apalutamide will minimize the extent or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medication that are CYP2C19 substrates may result in reduce publicity to these remedies.tazemetostat will decrease the extent or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Observe for indications of respiratory depression That could be bigger than in any other case predicted and decrease muscle mass relaxant dosage as essential.
aprepitant will raise the stage or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Diazepam may possibly interfere with metabolism of substrates for CYP2C19 and CYP3A4 leading to a possible drug-drug interaction
Reserve concomitant prescribing of such drugs in patients for whom other cure options are insufficient. Limit dosages and durations to your minimal required. Observe intently for signs of respiratory despair and sedation.
cannabidiol will boost the amount or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Intently. Take into account lowering the dose of sensitive CYP2C19 substrates, as clinically appropriate, when coadministered with cannabidiol.
Abuse and misuse of benzodiazepines typically (although not constantly) entail usage of doses higher than the most proposed dosage and generally entail concomitant use of other drugs, Liquor, and/or illicit substances, which is associated with an elevated frequency of serious adverse results, together with respiratory melancholy, overdose, or Dying
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Concomitant usage of benzodiazepines and opioids could bring about profound sedation, respiratory melancholy, coma, and Dying
Drugs which have constraints apart from prior authorization, amount limitations, and phase therapy affiliated with Every prescription.
zafirlukast will raise the amount or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Comment: Teduglutide may well improve absorption of concomitant PO remedies; caution with with medicines get more info requiring titration or All those using a slim therapeutic index; dose adjustment might be necessary.
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